Protooncogene Bcl-2 and Gleason Score in Prostate Cancer
نویسندگان
چکیده
The aim of this study was to analyse the relationship between the expression of the bcl-2 proto-oncogene and the histological grading of prostate cancer according to the Gleason score. To study the prognostic significance of Bcl-2 over expression in prostate cancer, 36 consecutive radical prostatectomy specimens were examined by immunohistochemistry. Bcl-2 was associated with malignant phenotype. Bcl-2 over expression (found in 14 – 38.89% tumours) was associated with high Gleason score. These data suggest that altered expression of Bcl-2 plays a role in prostate cancer progression.
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